Table 2 Definitions, calculations and interpretations of introduced terms
deposited energy | Edep | Calculation: Is the volume inside the isodose levels multiplied by the density ρ and the assigned dose and summed up for the isodose levels 20, 30, 40, 60, 80, 90 and 95%. Interpretation: An estimation of total absorbed radiation energy. |
chromosomal aberration correction factor | cf | Calculation: Is derived from a linear quadratic fit for the induction of chromosomal aberrations in dependence of dose. Interpretation: chromosomal aberrations are non-linear induced in dependence of dose. In low dose areas relative lower amounts of aberrations are induced compared to higher dose regions. |
effective deposited energy | \( {E}_{dep}^{eff} \) | Calculation: Is calculated according to the deposited energy while including the chromosomal aberration correction factor (cf) for each isodose level. Interpretation: The dose dependence of the induction of chromosomal aberrations is included. |
estimated average dose | EAD | Calculation: Is the deposited/absorbed radiation energy of an individual divided by the mass of this individual. Interpretation: It should reflect the exposed average dose of the blood and respectively the blood lymphocytes. |
normalized breaks per metaphase | B/Mnorm | Calculation: The B/M of an individual is multiplied by the average EAD of the whole cohort divided by the EAD of the individual. Interpretation: The B/M values of all individuals are normalized to the same dose. |
radiosensitivity factor | -- | Calculation: The breaks per metaphase of an individual divided by the average B/M of all individuals for the 2Gy ex vivo irradiation. Interpretation: A factor for each individual giving the deviation from the average radiosensitivity expressed as chromosomal aberrations. |