Fig. 6

Losartan treatment increased tumor vascular density and significantly decreased tumor hypoxia in MCa-M3C orthotopic tumors. a Increases in CD31 positive vascular area after losartan treatment, which is not statistically significant (Losartan vs. Control, P = 0.2147). b Losartan treatment significantly deceases hypoxia measured as pimonidazole positive area (Losartan vs. Control, Unpaired t test, P = 0.0002) in MCa-M3C tumor tissues (N = 5–10 areas/group)