Table 1 Chemokines in radiation response

CCL2

Normal cell

Human pulmonary AEC cells

Autocrine (CCR4)

Lung fibrosis

[42]

Normal cell

(Myo)fibroblasts

Neutrophiles

Liver damage

[49]

Normal cell

Irradiated brain(not specific)

Microglial

CNS injury

[48]

Cancer cell

A549, H157

Macrophage

Tumor promoting

[35]

Cancer cell

Mouse pancreatic cancer cell lines

Inflammatory monocytes and macrophages

Radioresistance

[36]

Cancer cell

HT1080, MPNST724, SK-LMS1,SW684

Th1/Tc1 T cells

Tumor control

[38]

Cancer cell

TC1 cells

Monocytes and CCR2(+) regulatory T cells

Radioresistance

[39]

Cancer cell

MC38, LLC cells

CCR2(+) MDSC

Radioresistance

[37]

Cancer cell

CNE2, HONE1, SUNE2 cells

Cancer cell

Radioresistance, metastasis and epithelial-mesenchymal transition

[40]

CCL3

Normal cell

Irradiated lung tissue (not specific)

CCR1(+) CD4 and CD8 T cells, and macrophages

Radiation-induced lung injury

[60]

Normal cell

Human conduit arteries

Not specific

Cardiovascular disease after irradiation

[61]

CCL5

Normal cell

Human pulmonary AEC cells

Autocrine (CCR4)

Pulmonary fibrosis

[42]

Normal cell

Endothelial cells

CCR5(+) hematopoietic cells

Hematopoietic regeneration

[80]

Cancer cell

Eca109, Kyse150 cells

Macrophages

Cellular Metastasis

[72]

Cancer cell

Mesenchymal stem cells

CCR5(+) macrophages

Lung Metastasis

[73]

Cancer cell

A549, H157 cells

Macrophage

Tumor promoting

[35]

Cancer cell

B16 cells

CD8+ T cell

Tumor control

[76]

CCL8

Normal cell

Irradiated lung tissues (not specific)

Macrophage

Lung metastasis

[86]

Normal cell

Irradiated hippocampal (not specific)

Not specific

Cognitive impairments

[47]

CCL11

Normal cell

Pericryptal alpha-SMA(+) cells

CCR3(+) Eosinophil

Radiation-induced intestinal fibrosis

[97]

Normal cell

Irradiated skin

Eosinophil

Radiation-induced skin injury

[94]

Normal cell

Dermal fibroblasts

Eosinophil

Eosinophilia

[96]

Normal cell

Endothelial cells

Not specific

Radiation-induced brain tissue damage

[95]

CCL20

Cancer cell

LLC cells

DC, lymphocytes

Tumor control

[102]

CCL22

Normal cell

Human NPC cell lines, patient-derived tumor xenograft tumors

CCR4(+) CD8 T cell

Tumor control

[106]

Normal cell

Irradiated lung tissues(not specific)

Alveolar lymphocytes and alveolar macrophages

Radiation pneumonitis/pulmonary fibrosis

[101]