Fig. 4

Increased proinflammatory mediators following WBRT in immunocompetent and immunocompromised mice. A–F Significant increase of TNF-α in the serum of WT mice immediately after WBRT (15.5 Gy) (A). Significant increase of TNF-α in the serum of athymic nude mice 12H post-WBRT (B). The fold changes of TNF-α concentrations in the serum following WBRT are significantly decreased 6H and 12H in WT mice and 12H in nude mice in comparison to WT immediate concentrations (C). CXCL1 is significantly increased in the brains of WT mice 6 and 12 h post-WBRT and in the brains of nude mice 12H post-WBRT (D, E). The fold changes of CXCL1 brain concentrations are significantly different between 12H timepoints of WT and nude strains (F) (p < 0.05)