Fig. 3

Fraction-wise analysis of dose-volume histogram (DVH)-parameters of a representative patient. The DVH-parameters of the gross target volume (GTV) (D95%(GTV)), planning target volume (PTV) (D95%(PTV)), ipsilateral lung (V20Gy(lungipsilateral)) and the heart (V5Gy (heart)) are shown as a function of treatment fractions for the three scenarios - without adaptive radiotherapy (ART) (blue), isoeffective ART (green), and isotoxic ART (red). The dashed grey line represents the respective DVH-parameter of the initial treatment plan