Fig. 4

A Cerebrospinal fluid TMB change of cohort before RT, during RT, and after RT. No significant difference was observed. CSF cerebrospinal fluid, TMB tumor mutation burden, RT radiation therapy, ns: no significance. B Kaplan–Meier curves of intracranial progression free survival (iPFS) comparing cerebrospinal fluid TMB decrease/undetectable and TMB increase/no change. C Plasma TMB change before RT, during RT, and after RT. No significant difference was observed. TMB tumor mutation burden, RT radiation therapy, ns no significance