Table 2 10 published abstracts of dosimetric studies of CBCT-guided ART
Disease site | Article | Number of Patients | Adapted Fractions Evaluated | Online ART procedural time | Outcomes |
|---|---|---|---|---|---|
Bladder | Azzarouali et al. [43] | 5 | – | Median 32 min | Improved PTV coverage with adaptive planning |
Bladder | Storm et al. [44] | 17 | 132 | Median 14 min | Intra-fractional variations during online ART of bladder cancer were limited, which may be explained by a strict bladder filling regimen |
Bladder | Zwart et al. [61] | 3 | – | – | Adapted plan coverage was ≥ 99% for all sessions, compared to only 2/73 session reached this level for scheduled plans |
Bony Metastases (Lumbar and Thoracic Spine, and Pelvis) | Nelissen et al. [57] | 8 | – | Average 36 min | Patients were satisfied with the procedure and completed consultation and treatment within two hours |
Brain | Kang et al. [49] | 7 | – | Average 44.2 min* | Adaptation improved target coverage and limited hotspots in the hippocampal avoidance zone |
Breast | Stanley et al. [58] | 2 | – | – | Daily adaptive replanning shows potential for reduced PTV margins and reduced OAR doses |
Head and Neck | Dohopolski et al. [60] | 10 | – | – | Adapted planning significantly improved median V100% coverage, homogeneity, and total median dose reduction in OARs |
Lung | Gonzalez et al. [46] | 18 | 68 | Average 15 min | Significant improved target coverage, dose conformity, and OAR sparing with online adaptive planning |
Lower lung and Upper Abdomen | Kim et al. [50] | 8 | 36 | Average 27 min | CBCT-guide ART demonstrated inter- and intra-fractional motion Residual motion of tumor was comparable to that of the imaging-surrogate within clinical PTV margins (5 mm) but a bit larger than the pre-configured gating window |
Liver, Pelvis, Abdomen, and Lung | Musunuru et al. [62] | 15 | – | – | Adapted plans had superior coverage, and nearly always met OAR tolerances compared to scheduled plans |