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Table 2 Primary study outcome and associated factors of TLN in Cox regression models

From: Risk of temporal lobe necrosis between proton beam and volumetric modulated arc therapies in patients with different head and neck cancers

 

NPC, n = 198 (%)

Non-NPC, n = 285 (%)

p value

Primary analysis

   

Occurrence of TLN

11 (5.6)

1 (0.4)

 

< 0.01#

 

Adjusted HR (95% CI)

p value

Multi-variable analysis

  

Cancer type (NPC vs. non-NPC)

13.35 (1.37, 130.61)

0.03†

Age

1.04 (0.98, 1.11)

0.16

T3/T4 stage

3.27 (0.80, 13.27)

0.10

Radiation doses

1.00 (1.00, 1.00)

0.01

Proton-beam therapy

1.67 (0.40, 6.94)

0.48

Re-irradiation

0.87 (0.04, 19.60)

0.93

Time to radiation therapy

1.00 (0.95, 1.05)

0.96

  1. TLN Temporal lobe necrosis; CI Confidence interval; HR Hazard ratio; NPC Nasopharyngeal carcinoma
  2. # Data was analyzed using the Chi-square test
  3. † Data was analyzed using a multivariable Cox regression model with backward selection
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Radiation Oncology

ISSN: 1748-717X

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