Fig. 3
From: PLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer
PLK4 inhibition enhances anticancer effects of RT via overamplification of centrioles. (A) Representative images depicting nuclear staining by DAPI (blue) and centriole staining by Centrin (green) in MDA-MB-468 cells. Immunocytochemistry for Centrin in (B) MDA-MB-468 (n = 4), (C) MDA-MB-231 (n = 3), and (D) SUM159 (n = 3) cells indicated a significant increase in centriole amplification in combination treatment compared to control (*), RT (α) or CFI-400945 (β) only (p ≤ 0.05)