Prognostic analysis of radiation-induced liver damage following carbon-ion radiotherapy for hepatocellular carcinoma

Table 3 Univariate analysis of dosimetric parameters associated with radiation-induced liver damage (RILD)

Variables	Patients with RILD	Patients without RILD	p-value
PTV (cm³)			0.282
≥58.9	10	70
<58.9	1	27
MLD (Gy(RBE))			0.282
≥7.1	10	70
<7.1	1	27
VS₅ (cm³)			0.097
≥637	5	69
<637	6	28
VS₁₀ (cm³)			0.048
≥506	8	91
<506	3	6
VS₁₅ (cm³)			0.138
≥697	6	75
<697	5	22
VS₂₀ (cm³)			0.123
≥714	6	77
<714	5	20
VS₃₀ (cm³)			0.036
≥739	6	81
<739	5	16
VS₄₀ (cm³)			0.118
≥937	4	60
<937	7	37
VS₅₀ (cm³)
≥968	4	61
<968	7	36	0.110
V₅ (%)			0.168
≥23.5	10	64
<23.5	1	33
V₁₀ (%)			0.099
≥19.7	10	63
<19.7	1	34
V₁₅ (%)			0.284
≥15.0	10	68
<15.0	1	29
V₂₀ (%)			0.507
≥12.9	9	68
<12.9	2	29
V₃₀ (%)
≥13.0	7	50
<13.0	4	47	0.534
V₄₀ (%)			0.534
≥10.8	7	50
<10.8	4	47
V₅₀ (%)			0.540
≥8.4	7	51
<8.4	4	46

PTV planning target volume, MLD mean liver dose, RBE relative biological effectiveness, VS_x, normal liver volume spared from less than × Gy (RBE), V_x, percentage of normal liver volume receiving equal to or more than × Gy (RBE)

ISSN: 1748-717X