Table 4 The outcome and the dosimetric parameters of image-guided adaptive brachytherapy

Gill et al.

IMRT (67.2%)

3D-CRT (31.3%)

MRI-guided

128

24.4

82.7 (74.8–93.3)

2-year OS: 85%; 3-year OS: 76.6%

2-year LC: 91.6%; 3-year LC: 91.6%

Grade ≥ 3 GI: 0.9%

Grade ≥ 3 UT: 0.9%

[10]

Murakami et al.

3D-CRT

CT-guided

42

23.2

70.3 (56.2–97.3)

2-year OS: 81.6%

2-year PFS: 54.4%

2-year LC: 80.2%

Grade ≥ 3 GI: 7.1%

[12]

Yoshio et al.

3D-CRT

CT-guided

97

31.8

66.3 (NA-NA)

1-year LC: 89%

2-year LC: 87%

Grade ≥ 3 GI: 6%

Grade ≥ 3 UT: 1%

[13]

Chi et al.

IMRT (64.9%)

3D-CRT (35.1%)

MRI-guided

97

21.1

91.7 (76.7-107.2)

2-year OS: 83.5%

2-year PFS: 71.1%

2-year LC: 94.8%

Grade ≥ 3 GI: 4.1%

Grade ≥ 3 UT: 0%

[11]

Ribeiro et al.

3D-CRT

MRI-guided

170

37

83.5 (66.3–98.9)

3-year OS: 73%;

5-year OS: 65%

3-year LC: 95%;

5-year LC: 95%

Grade ≥ 3 GI: 5%

Grade ≥ 3 UT: 6%

[14]

Kamran et al.

IMRT (29%)

3D-CRT (45%)

MRI-guided/CT-guided

29 (MRI)

27 (CT)

19.7 (MRI group)

18.4 (CT group)

MRI group: 79.8 (62.8–100.0)

CT group: 81.2 (57.9-100.2)

2-year LC: 96% (MRI group); 87% (CT group)

2-years OS: 84% (MRI group); 56% (CT group)

Grade ≥ 3 GI: 14.8% (CT group); 10.3% (MRI group)

Grade ≥ 3 UT: 3.7% (CT group); 10.3% (MRI group)

[15]