Table 2 PLR studies in breast malignancies
Year | Article | Total N | Study end-point(s) | Disease(s) | Treatment(s) | Important results |
|---|---|---|---|---|---|---|
2014 | Krenn-Pilko et al. [40] | 793 | CSS, OS, DMFS | Breast ca. | BCS + RT (90%), MRM (10%) | The elevated preoperative PLR was significantly associated with CSS and OS in multivariate analysis; increased PLR showed a significant association with the occurrence of distant metastases in univariate analysis |
2017 | Zhang et al. [41] | 5542 (12 studies) | DFS, OS | Breast ca. | Not specified | High PLR was associated with poor DFS and OS; higher incidence of high levels of PLR was noted in the stage II–IV group relative to the stage I group; the incidence of high levels of PLR was significantly different between the lymph node-positive and lymph node-negative groups and between the metastasis-positive and metastasis-negative group |
2020 | Van Berckelaer et al. [29] | 127 | RFS, DMFS, OS | Inflammatory breast ca. | Not specified except NACT | A lower PLR (≤ 210) was correlated with better RFS and DMFS; a high PLR was significantly associated with metastatic disease in multivariate analysis |