Clinical implications of the serum platelet-to-lymphocyte ratio in the modern radiation oncology era: research update and literature review

Table 5 PLR studies in hematological malignancies

Year	Article	Total N	Study end-point(s)	Disease(s)	Treatment(s)	Important results
2014	Wang et al. [61]	252	OS	Extranodal NK/T-cell lymphoma, nasal type	CRT/CTx/RT/No Tx	PLR significantly correlated with AAS, IPI, KPI and ALC; high PLR (> 185) was the independent prognostic factor of inferior OS, and PLR including prognostic model significantly predicted OS
2018	Reddy et al. [62]	338	FFP	Hodgkin lymphoma (classic type)	Unspecified	High pretreatment PLR was the independent prognostic factor of FFP in multivariate analysis
2023	Wen et al. [63]	183	PFS	MALT lymphoma	At least 1 antitumor therapy (S/RT/CTx /TT/Anti-HP therapy)	High pretreatment PLR (> 131.47) was the independent prognostic factor of PFS; PLR-based nomogram significantly predicted PFS

OS: Overall survival; NK: Natural killer; CRT: Chemoradiation therapy; CTx: Chemotherapy; RT: Radiation therapy; Tx: Treatment; PLR: Platelet to lymphocyte ratio; AAS: Ann arbor stage; IPI: International prognostic index; KPI: Korean prognostic index; ALC: Absolute lymphocyte count; FFP: Freedom from progression; PFS: Progression free survival; MALT: Mucosa-associated lymphoid tissue; S: Surgery; TT: Targeted therapy; HP: Helicobacter pylori

ISSN: 1748-717X