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Table 3 Multivariate analysis results for over 65% and 90% volume reduction at MRI evaluation

From: Association of increasing gross tumor volume dose with tumor volume reduction and local control in fractionated stereotactic radiosurgery for unresected brain metastases

  

Over 65% volume reduction

Over 65% volume reduction

Over 90% volume reduction

Over 90% volume reduction

OR

(95% CI)

p-value

VIF

OR

(95% CI)

p-value

VIF

OR

(95% CI)

p-value

VIF

OR

(95% CI)

p-value

VIF

GTV dose

D80 < 42 Gy

1

 

< 0.01

1.03

    

1

 

< 0.01

1.05

    
 

D80 > 42 Gy

3.68

(1.85–7.34)

      

4.70

(2.31–9.56)

      

GTV dose

D98 < 39 Gy

    

1

 

< 0.01

1.03

    

1

 

< 0.01

1.06

 

D98 > 39 Gy

    

4.68

(2.29–9.56)

      

6.41

(2.91–14.15)

  

Age (years)

22–65

1

 

0.01

1.04

1

 

0.01

1.03

1

 

0.06

1.05

1

 

0.05

1.05

 

> 65

0.45

(0.24–0.85)

  

0.43

(0.23–0.83)

  

0.58

(0.33–1.02)

  

0.57

(0.32–1.00)

  

Primary cancer

Lung and Breast

        

1

 

0.02

1.04

1

 

0.01

1.05

 

Others

        

0.46

(0.24–0.88)

  

0.42

(0.22–0.81)

  

Time for MRI evaluation

5–6.5 months

1

 

0.08

1.01

1

 

0.14

1.01

1

 

< 0.01

1.02

1

 

0.02

1.02

 

6.5–8.5 months

1.78

(0.93–3.42)

  

1.64

(0.85–3.16)

  

2.16

(1.23–3.80)

  

2.02

(1.14–3.56)

  
  1. Abbreviations MRI = magnetic resonance imaging; OR = odds ratio; CI = confidence interval; VIF = variance inflation factor; GTV = gross tumor volume