Table 3 Overall toxicities and corresponding increasing or decreasing trends recorded during different time points of the treatment and during follow-up
From: Targeted RT study: results on early toxicity of targeted therapies and radiotherapy
Toxicity | CTCAE degree | Baseline frequency (Number of patients) | End of irradiation frequency (Number of patients) | Trend | Follow-up frequency (Number of patients) | Trend |
|---|---|---|---|---|---|---|
Alopecia | °I | 4 | 10 | ↑ | 14 | ↑ |
°II | 1 | 2 | ↑ | 15 | ↑ | |
°III | 0 | 0 | → | 2 | ↑ | |
Impaired Concentration | °I | 9 | 15 | ↑ | 16 | ↑ |
°II | 2 | 1 | ↓ | 3 | ↑ | |
°III | 0 | 0 | → | 0 | → | |
Impaired Memory | °I | 10 | 7 | ↓ | 15 | ↑ |
°II | 1 | 1 | → | 2 | ↑ | |
°III | 0 | 0 | → | 0 | → | |
Vertigo | °I | 11 | 8 | ↓ | 17 | ↑ |
°II | 0 | 0 | → | 1 | ↑ | |
°III | 0 | 0 | → | 0 | → | |
Fatigue | °I | 65 | 75 | ↑ | 79 | ↑ |
°II | 11 | 16 | ↑ | 11 | ↓ | |
°III | 1 | 1 | → | 0 | ↓ | |
Dysphagia | °I | 16 | 20 | ↑ | 12 | ↓ |
°II | 1 | 4 | ↑ | 1 | ↓ | |
°III | 1 | 3 | ↑ | 2 | ↓ | |
Mucositis | °I | 0 | 5 | ↑ | 0 | ↓ |
°II | 0 | 1 | ↑ | 1 | → | |
°III | 0 | 0 | → | 0 | → | |
Xerostomia | °I | 1 | 5 | ↑ | 7 | ↑ |
°II | 0 | 1 | ↑ | 0 | ↓ | |
°III | 0 | 0 | → | 0 | → | |
Hyperpigmentation | °I | 5 | 7 | ↑ | 9 | ↑ |
°II | 0 | 1 | ↑ | 0 | ↓ | |
°III | 0 | 0 | → | 0 | → | |
Radiogenic Dermatitis | °I | 11 | 34 | ↑ | 9 | ↓ |
°II | 1 | 11 | ↑ | 0 | ↓ | |
°III | 0 | 2 | ↑ | 0 | ↓ | |
Fibrosis | °I | 5 | 7 | ↑ | 14 | ↑ |
°II | 0 | 0 | → | 1 | ↑ | |
°III | 0 | 0 | → | 0 | → | |
Breast edema | °I | 0 | 4 | ↑ | 4 | → |
°II | 0 | 0 | → | 0 | → | |
°III | 0 | 0 | → | 0 | → | |
Dyspnea | °I | 32 | 22 | ↓ | 35 | ↑ |
°II | 1 | 0 | ↓ | 7 | ↑ | |
°III | 1 | 1 | → | 0 | ↓ | |
Dry Cough | °I | 23 | 24 | ↑ | 36 | ↑ |
°II | 3 | 1 | ↓ | 1 | → | |
°III | 0 | 0 | → | 0 | → | |
Nausea | °I | 1 | 4 | ↑ | 2 | ↓ |
°II | 0 | 0 | → | 0 | → | |
°III | 0 | 0 | → | 0 | → | |
Pain | °I | 2 | 6 | ↑ | 6 | → |
°II | 2 | 2 | → | 0 | ↓ | |
°III | 0 | 0 | → | 0 | → | |
Dysuria | °I | 1 | 1 | → | 1 | → |
°II | 0 | 0 | → | 0 | → | |
°III | 0 | 0 | → | 0 | → | |
Urinary Incontinence | °I | 1 | 1 | → | 1 | → |
°II | 0 | 0 | → | 0 | → | |
°III | 0 | 0 | → | 0 | → | |
Nycturia | °I | 3 | 3 | → | 5 | ↑ |
°II | 0 | 1 | ↑ | 0 | ↓ | |
°III | 0 | 0 | → | 0 | → |