Fig. 3

Fibrosis before and after BT versus BT dose for representative patient. (A) Anatomic T2-weighted images with color-overlaid BT-dose distribution shown for a representative patient. HR-CTV is shown in the green color wash. (B, C) FDense images pre-BT (B) and post-BT (C) shown with the 50%, 100% BT-isodose lines, overlaid in color with the prescribed HR-CTV (green), the pre-BT (purple) and the post-BT (blue) segmented remnant tumor. (D) Scatter plot showing the mean FDense SI within the “responsive region” HR-CTV, which excludes the remnant tumor post-BT, irradiated by the 50%, 100%, 150%, and 200% of BT-dose prescription