Genetic markers of late radiation toxicity in the era of image-guided radiotherapy: lower toxicity rates reduce the predictive value of γ-H2AX foci decay ratio in patients undergoing pelvic radiotherapy

Table 3 Moderate and severe adverse events as determined according to the CTCAEv4 and EORTC

Toxicity		Physician-assessed		Patient-reported
Toxicity		Moderate (n = 19)	Severe (n = 5)	Moderate (n = 21)	Severe (n = 6)
Bowel
	Abdominal pain	2 (50)		5 (100)
	Diarrhea	7 (86)		3 (100)	1 (100)
	Fecal incontinence	4 (100)		2 (50)	1 (100)
	Rectal hemorrhage	1 (0)		1 (0)	1 (100)
	Constipation	1 (0)		3 (67)
	Feeling bloated			3 (0)	1 (0)
	Proctitis^†		1 (100)
Urinary tract
	Urinary tract pain	1 (0)		1 (0)	1 (0)
	Frequency	3 (0)		10 (10)	2 (0)
	Incontinence	3 (67)		3 (33)	1 (100)
	Retention	1 (0)	3 (100)	1 (100)
Gynecologic
	Vaginal inflammation/mucositis	4 (100)	1 (100)		2 (100)
Other
	N. peroneus neuropathy^†	1 (0)
	Insufficiency fractures^†	1 (100)
	Unilateral lymphedema lower extremity^†	1 (100)

Abbreviations: CTCAEv4 = Common Terminology Criteria for Adverse Events version 4.0; EORTC = European Organization for Research and Treatment of Cancer.
^† These events were reported by physicians in the free space of our toxicity reporting system and are regarded most likely related to radiotherapy.
Data are numbers of patients with percentage of women between brackets.
Physicians: 30 grade 2 events were recorded in 19 patients and 5 grade 3 events were recorded in 5 patients. Patients: 35 grade 2 events were recorded in 21 patients and 10 grade 3 events were recorded in 6 patients.
A repeated symptom was counted as a single event.

ISSN: 1748-717X