Fig. 1

Workflow. LARC: locally advanced rectal cancer; LCCRT: long course concurrent radiotherapy and chemotherapy; MRgART-SIB: MRI-guided simultaneous integrated boost radiotherapy; CAPOX: capecitabine and oxaliplatin; FOLFOX: 5-fluorouracil, leucovorin and oxaliplatin; TME: total mesorectal excision