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Table 4 Toxic and side effect according to radiation dose

From: Dose escalation in radical radio(chemo)therapy for cervical and upper thoracic esophageal cancer with 3DCRT/IMRT (ChC&UES): a multicenter retrospective study

 

SD

(≤55 Gy)

HD-conventional

(55–63 Gy)

HD-ultra

(≥ 63 Gy)

χ²

P

Radiation esophagitis

   

10.719

0.097

0 grade

58(30.5%)

285(36.4%)

94(41.2%)

  

1 grade

51(26.8%)

242(30.9%)

68(29.8%)

  

2 grade

65(34.2%)

199(25.4%)

51(22.4%)

  

≥ 3 grade

16(8.4%)

56(7.2%)

15(6.6%)

  

Radiation pneumonitis

   

7.977

0.240

0 grade

163(91.1%)

685(91.7%)

198(87.6%)

  

1 grade

8(4.5%)

45(6.0%)

20(8.8%)

  

2 grade

6(3.4%)

9(1.2%)

5(2.2%)

  

≥ 3 grade

2(1.1%)

8(1.1%)

3(1.3%)

  

Myelosuppression

   

13.249

0.039

0 grade

54(35.1%)

195(30.8%)

58(29.4%)

  

1 grade

50(32.5%)

175(27.6%)

52(26.4%)

  

2 grade

33(21.4%)

168(26.5%)

42(21.3%)

  

≥ 3 grade

17(11%)

95(15%)

45(22.8%)

  
  1. SD: Standard dose; HD: High dose;