Table 4 Univariate and multivariate Cox regression analysis on OS and PFS
Variable | OS (N = 76, events = 70) | PFS (N = 76, events = 76) | ||||||
|---|---|---|---|---|---|---|---|---|
Univariable model | Multivariable model | Univariable model | Multivariable model | |||||
HR (95% CI) | Pa | HR (95% CI) | pa | HR (95% CI) | pa | HR (95% CI) | pa | |
Group (refer to LEN) | 0.54(0.32–0.89) | 0.015 | 0.38(0.22–0.65) | 0.000 | 0.54(0.33–0.87) | 0.012 | 0.46(0.28–0.75) | 0.002 |
Gender (refer to Male) | 1.04(054 − 2.00) | 0.901 |  |  | 1.13(0.60–2.11) | 0.702 |  |  |
Age (refer to < 55 years) | 1.12(0.70–1.80) | 0.635 |  |  | 1.18(0.75–1.87) | 0.476 |  |  |
Etiology (refer to HBV) | 2.08(0.64–6.74) | 0.223 |  |  | 2.99(0.91–9.82) | 0.071 | 2.55(0.74–8.78) | 0.138 |
Child-Pugh classification (refer to A) | 1.57(0.67–3.66) | 0.297 |  |  | 1.28(0.55–2.98) | 0.567 |  |  |
ECOG PS (refer to 0) | 1.39(0.86–2.25) | 0.174 |  |  | 1.30(0.82–2.06) | 0.261 |  |  |
Number Of Tumors (refer to < 3) | 3.00(1.77–5.07) | 0.000 | 3.00(1.72–5.26) | 0.000 | 2.75(1.64–4.60) | 0.000 | 2.58(1.51–4.40) | 0.001 |
Tumor size (refer to < 5 cm) | 1.41(0.98–2.02) | 0.065 | 1.34(0.91–1.98) | 0.136 | 1.15(0.83–1.59) | 0.416 |  |  |
PVTT (refer to Vp1) | 2.45(1.71–3.50) | 0.000 | 2.39(1.62–3.53) | 0.000 | 1.63(1.21–2.20) | 0.001 | 1.62(1.19–2.20) | 0.002 |
ALBI grade (refer to 1) | 1.43(0.87–2.37) | 0.164 |  |  | 1.34(0.83–2.17) | 0.236 |  |  |
AFP (refer to ≤ 200 ng/mL) | 0.75(0.47–1.22) | 0.244 |  |  | 0.88(0.56–1.39) | 0.586 |  |  |
PLT (refer to < 100 × 109/L) | 0.68(0.39–1.20) | 0.188 |  |  | 0.68(0.40–1.17) | 0.165 |  |  |
WBC (refer to < 4 × 109/L) | 0.98(0.56–1.72) | 0.945 |  |  | 0.97(0.57–1.66) | 0.924 |  |  |
Previous local treatment (refer to Absence) | 0.73(0.39–1.37) | 0.324 |  |  | 0.62(0.34–1.13) | 0.115 |  |  |