Table 1 Baseline characteristics and proportion of antipsychotics use

Sex

Male

277,881 (40.58%)

27,789 (67.58%)

9.09

64,336 (59.92%)

6398 (78.71%)

9.05

Female

406,898 (59.42%)

13,329 (32.42%)

3.17

43,035 (40.08%)

1731 (21.29%)

3.87

Age (Mean, SD)

57.08 (14.19)

64.63 (12.72)

60.28 (11.77)

63.33 (11.03)

< 30

19,395 (2.83%)

465 (1.13%)

2.34

1002 (0.93%)

50 (0.62%)

4.75

30–39

53,790 (7.86%)

1047 (2.55%)

1.91

4188 (3.9%)

175 (2.15%)

4.01

40–49

130,236 (19.02%)

3309 (8.05%)

2.48

13,403 (12.48%)

642 (7.9%)

4.57

50–59

178,722 (26.1%)

8253 (20.07%)

4.41

29,758 (27.72%)

1895 (23.31%)

5.99

60–69

157,668 (23.02%)

11,971 (29.11%)

7.06

34,074 (31.73%)

2823 (34.73%)

7.65

70–79

113,708 (16.61%)

11,834 (28.78%)

9.43

21,585 (20.1%)

2182 (26.84%)

9.18

≥80

31,260 (4.56%)

4239 (10.31%)

11.94

3361 (3.13%)

362 (4.45%)

9.72

CCI (Mean, SD)

3.46 (2.77%)

3.82 (2.88)

3.64 (2.89)

4.17 (3.07)

0

53,628 (7.83%)

2636 (6.41%)

4.69

8328 (7.76%)

441 (5.43%)

5.03

1

126,187 (18.43%)

6386 (15.53%)

4.82

19,104 (17.79%)

1210 (14.88%)

5.96

2

149,736 (21.87%)

7992 (19.44%)

5.07

22,487 (20.94%)

1489 (18.32%)

6.21

≥ 3

355,228 (51.87%)

24,104 (58.62%)

6.35

57,452 (53.51%)

4989 (61.37%)

7.99

Medical history

Hypertension (I10-I15)

291,622 (42.58%)

24,386 (59.3%)

7.72

50,101 (46.66%)

4662 (57.35%)

8.51

Dyslipidemia (E78)

400,651 (58.50%)

28,515 (69.35%)

6.64

62,321 (58.04%)

5566 (68.47%)

8.20

Diabetes Mellitus

(E10-E14)

257,763 (37.64%)

22,935 (55.78%)

8.17

45,920 (42.76%)

4566 (56.17%)

9.04

Chronic renal Disease (N17-N19)

94,529 (13.8%)

10,884 (26.47%)

10.33

15,400 (14.34%)

1964 (24.16%)

11.31

Stroke (I60-I69)

31,721 (4.63%)

3862 (9.39%)

10.85

4568 (4.25%)

557 (6.85%)

10.87

Peripheral Vascular Disease (I70-I79)

155,785 (22.74%)

13,682 (33.27%)

8.07

26,338 (24.52%)

2674 (32.89%)

9.22

Myocardial Infarction (I21, I22)

18,227 (2.66%)

2321 (5.64%)

11.30

3321 (3.09%)

452 (5.56%)

11.98

Anemia

(D50-53, D55-59)

145,551 (21.25%)

11,904 (28.95%)

7.56

22,131 (20.61%)

2025(24.91%)

8.38

Psychiatric History

181,908 (26.56%)

28,664 (69.71%)

13.61

30,399 (28.31%)

5439 (66.90%)

15.17

Bipolar disorder

(F30, F31)

3797 (0.55%)

5952 (14.4%)

61.05

758 (0.71%)

1073 (13.20%)

58.60

Psychotic disorder (F20-F29 )

2920 (0.42%)

4073 (9.91%)

58.24

755 (0.70%)

955 (11.74%)

55.84

Depressive disorder (F32-F34)

126,753 (18.51%)

14,953 (36.36%)

10.55

18,628 (17.35%)

2714 (33.38%)

12.72

Delirium (F05)

3716 (0.54%)

1749 (4.25%)

32.00

638 (0.59%)

249 (3.06%)

28.07

Other psychiatric disorders (F00-F99)

98,487(14.38%)

10,834 (26.35%)

9.91

14,591(14.52%)

2214 (27.23%)

14.01