Skip to main content

Table 2 Dose–volume parameters of planned and recalculated dose

From: Bone matching versus tumor matching in image-guided carbon ion radiotherapy for locally advanced non-small cell lung cancer

ROI

Parameters

 

Dose distribution

 

Plan-O

Plan-T

Plan-B

iGTV

V95% (%)

100

99.93*, **

99.60*

  

(99.39–100)

(88.88–100)

(82.088-100)

 

D95%

1.016

0.999*, **

0.994*

  

(0.960–1.082)

(0.926–1.057)

(0.915–1.054)

 

D99%

1.008

0.978*, **

0.967*

  

(0.953–1.073)

(0.769–1.031)

(0.790–1.024)

 

Relative median dose

1.037

1.033**

1.032*

  

(1.008–1.110)

(1.008–1.110)

(0.982–1.103)

 

HI

1.037

1.076*, **

1.080*

  

(1.020–1.129)

(1.032–1.185)

(1.032–1.208)

CTV

V95%

100

99.67*, **

99.20*

  

(99.58–100)

(95.918-100)

(93.46–100)

 

D95%

1.080

1.052*, **

1.030*

  

(1.025–1.172)

(0.957–1.143)

(0.924–1.136)

 

D99%

1.047

0.989*, **

0.966*

  

(0.997–1.154)

(0.611–1.113)

(0.668–1.104)

 

Relative median dose

1.139

1.140**

1.037

  

(1.085–1.211)

(1.093–1.181)

(1.082–1.187)

Lungs

V5 (%)

24.89

24.48

24.03

  

(11.54–48.05)

(11.44–47.40)

(10.74–47.69)

 

V20 (%)

16.37

17.17*

16.70

  

(6.04–30.99)

(7.29–32.04)

(7.70-32.55)

 

Mean dose (Gy(RBE))

9.43

9.68

9.71

  

(3.76–15.36)

(4.62–16.50)

(4.49–17.56)

Heart

V40 (%)

2.76

2.61**

2.56

  

(0-11.31)

(0-12.38)

(0-13.48)

 

Mean dose (Gy(RBE))

3.48

3.55**

2.95

  

(0.07–12.85)

(0.04–15.31)

(0.03–15.09)

Spinal cord

Max dose (Gy(RBE))

26.44

24.55

27.74

  

(4.01–56.89)

(3.27–50.49)

(3.65–52.46)

Esophagus

Max dose (Gy(RBE))

74.62

75.98

74.95*

  

(4.05–86.02)

(3.67–87.80)

(3.82–87.65)

 

Mean dose (Gy(RBE))

13.26

12.03**

11.95

  

(0.18–40.05)

(0.14–42.94)

(0.20-42.98)

Bronchial tree

Max dose (Gy(RBE))

83.38

85.05*, **

86.12*

  

(4.58–89.80)

(5.23–95.55)

(3.22–96.54)

  1. Data are presented as median (range)
  2. D95% (D99%), the dose covering 95% (99%) of the iGTV or CTV as a ratio of the prescribed dose; V95%, percentage of target volume that included 95% of the prescribed dose area; V5 and V20, percentage of the total lung volume receiving 20 Gy(RBE) and 5 Gy(RBE); V40, percentage of the heart receiving 40 Gy(RBE)
  3. * Indicates significant difference compared with the Plan-O
  4. ** Indicates significant difference compared with the Plan-B