Fig. 2

Modelled survival curves plotted against determined recurrence data of medulloblastoma cell lines genetically modified to overexpress MYC

Probability of recurrence after fractionated irradiation as determined by non-linear regression of survival data of the medulloblastoma cell lines ONS76/mCherry (A), ONS76/MYC (B), UW228-3/mCherry (C) and UW228-3/MYC (D). The solid lines depict the derived estimated survival curves for the denoted amount of cells after splitting of the full dose D (x-axis) in 2 (orange), 4 (green) or 8 (blue) fractionations. The coloured dashed lines represent the corresponding high and low 95% confidence intervals. The actual determined data for the chosen conditions (lower cell number and 2, 4, and 8 fractions) is shown as open diamond (2x fract.), square (4x fract.) and triangle (8x fract.) data points using the same colour code