Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors

Table 2 Dosimetric analysis of the actual doses received by OARs when utilizing LRT as a boost plan in comparison to CRT

Items	Dosimetry parameters	LRT	CRT	LRT + AD	CRT + AD	P-value
Lungs-GTV	Dmean (Gy)	0.97 ± 0.02	3.53 ± 0.34	10.36 ± 7.17	12.73 ± 1.85	0.010*
	V₅ (%)	1.01 ± 0.10	21.86 ± 5.73	43.10 ± 19.25	61.56 ± 5.14	< 0.001*
	V₁₀ (%)	0.00 ± 0.00	11.18 ± 3.16	34.36 ± 16.92	48.90 ± 4.47	< 0.001*
	V₁₅ (%)	0.00 ± 0.00	4.94 ± 0.93	22.25 ± 15.26	28.27 ± 5.54	0.001*
	V₂₀ (%)	–	–	15.66 ± 11.52	21.82 ± 3.14	< 0.001*
	V₃₀ (%)	–	–	9.62 ± 7.36	12.63 ± 1.29	< 0.001*
Heart	D_mean (Gy)	1.04 ± 0.64	2.84 ± 1.07	9.16 ± 6.04	10.34 ± 4.86	0.021*
Spinal cord	D_max (Gy)	5.54 ± 1.22	12.02 ± 1.98	32.44 ± 6.37	40.41 ± 5.11	0.007*

AD denoted the accumulated dose delivered in CRT mode for the initial 20 fractions, each prescribed at 2 Gy

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