Fig. 1

VMAT-STI protocol for brain metastases. a) Schematic diagram. b) Example of STI plan-ning with VMAT. Biologically Effective Dose (BED10) of 80 Gy (as red line of 43 Gy in 5 fractions in this case) is matched to the GTV marginal dose (as green line). BED10 of 50 Gy (as cyan line of 31 Gy in 5 fractions in this case) is matched to the PTV (GTV + 3 mm as yellow line). Tumor center dose is increased to at least 125% of the GTV marginal dose (as dark red line of 54 Gy in 5 fractions in this case)