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Table 2 Feasibility of active heart sparing planning regarding coverage of the target and constraints in the OARs and heart parameters (t-test results)

From: Development of heart-sparing VMAT radiotherapy technique incorporating heart substructures for advanced NSCLC patients

Active heart sparing group

Structure

Constraint

Parameter

Mean (SD)

Standard constraints

  

Lungs

MLD ≤ 20 Gy

MLD (Gy)

14,546 (3.896)

 

V20 Gy ≤ 35%

V20 Gy (%)

25,871 (7.318)

 

V5 Gy < 65%

V5 Gy (%)

58,500 (14.872)

Esophagus

D mean 34 Gy

D mean (Gy)

18,195 (7.486)

 

V55 Gy ≤ 33%

V55 Gy (%)

11,803 (10.517)

 

V60 Gy ≤ 7%

V60 Gy (%)

6,450 (8.526)

 

maximal dose < 105% of prescribed dose

Vol > 105% prescribed dose (cc)

0,004 (0.020)

Heart sparing constraints

  

Heart

MHD ≤ 10 Gy

MHD (Gy)

6,208 (2.884)

 

V30 Gy < 20%

V30 Gy (%)

4,305 (3.140)

Left ventricle

D mean < 3 Gy

D mean Gy

2,276 (1.756)

 

V5 Gy < 17%

V5 Gy (%)

8,061 (17.065)

 

V23 Gy < 5%

V23 Gy (%)

0,267 (1.262)

LAD

D max < 17 Gy

D max Gy

6,658 (3.324)

 

V15Gy < 10%

V15 Gy (%)

0,090 (0.469)

 

V30 Gy < 2%

V30 Gy (%)

0,000 (0.000)

Heart base

D mean < 9 Gy

D mean (Gy)

5,771 (2.003)

PTV

Volume (cc)

 

293,041 (189.244)

 

D2% (Gy)

 

68,388 (1.485)

 

D98% (Gy)

 

56,642 (16.206)

  1. PTV: planning target volume; SD, standard deviation, LAD: left anterior discending coronary artery; D mean: Mean dose; D max: maximal dose; MLD: mean lung dose; MHD: mean heart dose