Incidence and predictors of lower extremity lymphedema after postoperative radiotherapy for prostate cancer

Radiation Oncology

Table 4 Univariate analysis of risk factors associated with lymphedema

Variable	Classification	p value	OR	95%CI
Age	> 65 vs. < 65 years-old	0.05	3.75	0.97	1.43
Age at time of RT	continuous	0.89	0.99	0.92	1.07
BMI	continuous	0.52	1.05	0.89	1.23
	25–30 vs. 0–25 kg/m²	0.96	0.96	0.25	3.72
	> 20 vs. 0–25 kg/m²	0.30	2.23	0.48	10.3
	> 30 vs. 0–30 kg/m²	0.72	1.25	0.36	4.32
Level of exercise	Moderate vs. Low	0.01	0.07	0.01	0.36
	High vs. Low	0.99	0.00	0.00	.
	Moderate/High vs. Low	0.01	0.06	0.01	0.30
Smoke	Yes vs. No	0.01	4.77	1.47	15.4
Pack/year	continuous	0.04	1.02	1.00	1.05
Hypertension	Yes vs. No	0.11	2.55	0.78	8.24
Cardiopathies	Yes vs. No	0.46	1.70	0.41	7.01
DM	Yes vs. No	0.03	5.65	1.11	28.7
PLND	Yes vs. No	0.16	3.00	0.62	14.3
N. of lymphnodes dissected	continuous	0.02	1.06	1.00	1.12
	> 15 vs. < 15	0.16	2.46	0.69	8.75
	None vs. < 15	0.44	0.51	0.09	2.82
	> 15 vs. none/<15	0.05	3.14	0.98	9.99
WPRT	Yes vs. No	0.78	1.18	0.34	4.11
RT Boost to lymphnodes	Yes vs. No	0.03	5.65	1.11	28.7
Time interval RP–RT	continuous	0.03	0.97	0.94	0.99
	> 40 vs. < 40 months	0.02	0.16	0.03	0.77
	> 30 vs. < 30 months	0.03	0.25	0.07	0.88
Total PTV	continuous	0.87	1.00	0.99	1.00
	> 1400 vs. < 1400 cm3	0.64	0.76	0.24	2.39
	> 1300 vs. < 1300 cm3	0.68	1.27	0.39	4.10
PTV/BMI	continuous	0.88	1.00	0.97	1.02

Abbreviations: OR: odds ratio; CI: confidence interval; BMI: body mass index; DM: diabetes mellitus; PLND: pelvic lymph node dissection; N.: number; WPRT: whole pelvic radiotherapy; RT: radiotherapy; RP: radical prostatectomy; PTV: planning target volume

ISSN: 1748-717X