Table 4 Subgroup analysis comparing the PFS of HGG patients with V60 < 50% versus those with V60 ≥ 50% in the ipsilateral SVZ(Kaplan-Meier analysis)

Age

 ≥60y

 < 60y

10.0(7.2–12.8)

8.0(5.7–10.3)

4.0(2.4–5.6)

18.0(10.8–25.2)

0.013

0.006

Gender

 Male

 Female

10.0(7.4–12.6)

7.0(4.2–9.8)

16.0(10.4–21.6)

9.0(3.9–14.1)

0.102

0.605

Preoperative KPS score

 ≥80

 ≤70

7.0(4.1–9.9)

9.0(5.6–12.4)

18.0(11.9–24.1)

9.0(2.2–15.8)

0.074

0.685

Lesion number

 Multiple

 Single

6.0(3.4–8.6)

11.0(9.2–12.8)

8.0(2.6–13.4)

18.0(11.3–24.7)

0.219

0.314

Tumor size

 >3.5 cm

 ≤ 3.5 cm

10.0(7.3–12.7)

6.0(2.1–9.9)

16.0(10.1–21.9)

4.0(0.0-8.9)

0.094

0.833

WHO grading

 Grade 4

 Grade 3

8.0(6.7–9.3)

17.0(4.1–29.9)

16.0(9.3–22.7)

9.0(0.2–17.8)

0.006

0.551

Extent of resection

 Total

 Subtotal

10.0(6.3–13.7)

8.0(5.7–10.3)

18.0(11.5–24.5)

9.0(6.8–11.2)

0.148

0.266

Surgical approaches to the lateral ventricles

 Yes

 No

8.0(5.3–10.8)

10.0(6.6–13.4)

12.0(7.4–16.6)

16.0(7.9–24.1)

0.034

0.446

IDH1

 Mutant type

12

10.0(0.0-

18.0(9.0-26.9)

0.839

 Wild type

28.6)8.0(6.0–10.0)

12.0(9.0–15.0)

0.072

Ki67 expression

 ≤10%

 >10%

NA

8.0(5.4–10.6)

6.0 (2.1–9.9)

16.0(11.4–20.6)

0.819

0.097

MGMT

 Methylation

 Unmethylation

17.0(0.0-34.6)9.0(6.4–11.6)

11.0(5.7–16.3)

12.0(8.1–15.9)

0.999

0.249