Table 5 Subgroup analysis comparing the OS of HGG patients with V60 < 50% versus those with V60 ≥ 50% in the ipsilateral SVZ
Clinical characteristics | N | Median OS (95% CI) | P | |
|---|---|---|---|---|
V60Gy < 50% | V60Gy ≥ 50% | |||
Age | Â | Â | Â | Â |
 ≥60y  < 60y | 14 36 | 24.0(4.7–43.3) 18.0(14.6–21.4) | 18.0(14.7–21.3) 38.0(32.2–43.9) | 0.617 0.053 |
Gender | Â | Â | Â | Â |
 Male  Female | 30 20 | 18.0(12.1–23.9) 24.4(16.7–32.1) | 35.0(14.6–55.4) 30.1(25.6–34.6) | 0.149 0.253 |
Preoperative KPS score | Â | Â | Â | Â |
 ≥80  ≤70 | 26 24 | 27.7(20.8–34.5) 15.0(11.6–18.4) | 29.2(23.1–35.2) 28.0(26.9–43.1) | 0.858 0.213 |
Lesion number | Â | Â | Â | Â |
 Multiple  Single | 15 35 | 16.0(13.7–18.3) 24.7(19.5–29.9) | 19.0(15.7–22.3) 34.4(30.5–38.3) | 0.410 0.057 |
Tumor size | Â | Â | Â | Â |
 >3.5 cm  ≤ 3.5 cm | 42 8 | 24.0(11.1–36.9) 16.0(4.9–27.1) | 38.0(29.0–47.0) 16.0(5.5–26.5) | 0.068 0.889 |
WHO grading | Â | Â | Â | Â |
 Grade 4  Grade 3 | 36 14 | 16.0(8.4–23.6) 25.0(10.0–40.0) | 38.0(26.4–49.6) 35.0(18.8–51.2) | 0.035 0.982 |
Extent of resection | Â | Â | Â | Â |
 Total  Subtotal | 32 18 | 25.0(16.4–33.6) 16.0(13.7–18.3) | 38.0(23.4–52.6) 35.0(9.3–60.7) | 0.098 0.204 |
Surgical approaches to the lateral ventricles | Â | Â | Â | Â |
 Yes  No | 19 31 | 16.0(14.6–17.4) 27.8(22.0-33.5) | 30.0(10.7–49.3) 33.2(28.1–38.2) | 0.008 0.562 |
IDH1 | Â | Â | Â | Â |
 Mutant type  Wild type | 12 38 | NA 16.0(12.2–19.9) | NA 35.0(23.9–46.1) | 0.371 0.012 |
Ki67 expression | Â | Â | Â | Â |
 ≤10%  >10% | 6 44 | NA 18.0(10.7–25.3) | NA 38.0(18.1–57.9) | 0.317 0.095 |
MGMT | Â | Â | Â | Â |
 Methylation  Unmethylation | 13 32 | NA 16.0(2.9–29.1) | 30.0(13.4–46.6) 38.0(32.3–43.7) | 0.447 0.047 |