Table 4 Performance of the Comb2 model at 3 operating points
Target Sensitivity | Training cohort | Internal test cohort | External test cohort | |||
|---|---|---|---|---|---|---|
Actual sensitivity | Specificity | Actual sensitivity | Specificity | Actual sensitivity | Specificity | |
98% | 98.3% | 29.6% (58/196) | 96.8% | 1.9% (1/52) | 100.0% | 9.1% (2/22) |
95% | 95.4% | 32.1% (63/196) | 93.6% | 9.6% (5/52) | 90.0% | 27.3% (6/22) |
90% | 90.2% | 79.6% (156/196) | 70.2% | 23.1% (12/52) | 80.0% | 36.4% (8/22) |