Table 2 Acute and chronic toxicity in smokers and non-smokers BC patients treated with adjuvant hypofractionated IMRT following BCS between 2009 and 2017
From: Smoking increases breast toxicity despite adjuvant hypofractionated IMRT in early breast cancer
Smokers (n = 177) | Nonsmokers (n = 389) | p-value | RR (95% CI) | Adjusted p-value** | Adjusted RR (95% CI)** | |
|---|---|---|---|---|---|---|
Acute toxicity | ||||||
Radiodermatitis (n, %) | 168 (94.9%) | 359 (92.3) | 0.253 | 1.028 (0.983 − 0.075) | 0.348 | 1.021 (0.978–1.066) |
Bleeding (n, %) | 2 (1.1%) | 4 (1.0) | 0.915 | 0.551 (0.062–0.898) | 0.878 | 1.096 (0 0.202- 5.939) |
Infection (n, %) | 6 (3.4%) | 5 (1.3) | 0.108 | 2.618 (0.809 − 0.463) | 0.395 | 1.776 (0.473–6.661) |
Chronic toxicity | ||||||
Fibrosis (n, %) | 63 (35.6%) | 96 (24.7) | 0.013 | 1.393 (1.076–0.802) | 0.014 | 1.369 (0.473–6.661) |
Edema (n, %) | 14 (7.9%) | 31 (8.0) | 0.879 | 0.954 [0.521-0.0745) | 0.644 | 0.860 (0.456–1.625) |
Pain (n, %) | 14 (7.9%) | 13 (3.3) | 0.024 | 2.271 (1.094–0.715) | 0.004 | 3.338 (1.461–7.625) |