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Table 2 Uni- and multivariate Cox proportional hazards regression analysis of patient- und tumor-related parameters regarding overall and progression-free survival (n = 99) for patients ≤ 45 years

From: Radiotherapy outcomes and risk factors for young patients with head-and-neck squamous cell carcinomas: a matched-pair analysis

Overall survival

Univariate

Multivariate

 

HR

95% CI

p

HR

95% CI

p

Age (continuous)

1.072

0.978–1.175

0.140

1.001

0.907–1.105

0.976

Gender (reference: female)

3.456

1.168–10.230

0.025

2.237

0.689–7.262

0.180

ECOG (continuous)

1.467

0.950–2.265

0.083

1.668

0.976–2.850

0.061

Treatment (reference: definitive radiation)

0.844

0.428–1.661

0.623

   

Smoking

1.553

0.723–3.334

0.258

   

Alcohol

1.987

0.971–4.069

0.060

2.522

1.172–5.426

0.018

Concomitant systemic treatment

1.193

0.630–2.258

0.588

   

Grading

1.307

0.706–2.421

0.394

   

T status

1.211

0.888–1.652

0.227

   

N status

1.503

1.046–2.160

0.028

1.266

0.807–1.986

0.305

Progression-free survival

Univariate

Multivariate

 

HR

95% CI

p

HR

95% CI

p

Age (continuous)

1.012

0.941–1.088

0.749

   

Gender (reference: female)

2.740

1.129–6.649

0.026

   

ECOG (continuous)

1.010

0.693–1.474

0.957

   

Treatment (reference: definitive radiation)

1.102

0.575–2.110

0.770

   

Smoking

1.200

0.639–2.252

0.571

   

Alcohol

1.355

0.762–2.410

0.301

   

Concomitant systemic treatment

1.181

0.677–2.060

0.559

   

Grading

1.307

0.757–2.256

0.337

   

T status

1.272

0.968–1.671

0.084

   

N status

1.161

0.858–1.570

0.333

   

Locoregional control

Univariate

Multivariate

 

HR

95% CI

p

HR

95% CI

p

Age (continuous)

0.988

0.909–1.073

0.767

   

Gender (reference: female)

2.700

0.805–9.055

0.108

2.869

0.848–9.710

0.090

ECOG (continuous)

0.679

0.422–1.092

0.110

0.654

0.402–1.061

0.086

Treatment (reference: definitive radiation)

1.531

0.627–3.741

0.350

   

Smoking

0.991

0.457–2.146

0.981

   

Alcohol

0.953

0.459–1.976

0.896

   

Concomitant systemic treatment

1.575

0.758–3.272

0.224

   

Grading

1.055

0.529–2.104

0.880

   

T status

1.165

0.823–1.649

0.389

   

N status

0.998

0.686–1.453

0.993

   

Distant metastasis free survival

Univariate

Multivariate

 

HR

95% CI

p

HR

95% CI

p

Age (continuous)

1.055

0.959–1.161

0.273

   

Gender (reference: female)

3.601

1.235–10.498

0.019

2.219

0.692–7.120

0.180

ECOG (continuous)

1.187

0.768–1.835

0.440

   

Primary treatment (reference: definitive radiation)

0.765

0.390–1.499

0.435

   

Smoking

1.375

0.646–2.923

0.407

   

Alcohol

1.803

0.881–3.689

0.106

1.694

0.862–3.329

0.126

Concomitant systemic treatment

1.258

0.674–2.349

0.472

   

Grading

1.636

0.872–3.069

0.125

1.616

0.843–3.099

0.149

T status

1.245

0.914–1.697

0.165

1.076

0.776–1.494

0.660

N status

1.476

1.037–2.102

0.031

1.242

0.834–1.848

0.286

  1. Statistically significant values printed in bold. CI, confidence interval; ECOG, eastern cooperative oncology group; HR, hazard ratio; UICC, union for international cancer control
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Radiation Oncology

ISSN: 1748-717X

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