Table 5 Multivariable logistic regression analysis of predictors of RT response
Characteristics | OR (95%CI) | P value |
|---|---|---|
All-inclusive model | ||
Sex | ||
Female | Ref | |
Male | 1.170(0.544–2.517) | 0.688 |
Age at diagnosis | ||
< 3 y | Ref | |
≥ 3 y | 0.855(0.296–2.468) | 0.773 |
Histology | ||
Non-large cell/anaplastic | Ref | |
Large cell/anaplastic | 0.614(0.100-3.757) | 0.598 |
Molecular grouping | ||
WNT | Ref | |
SHH | 0.137(0.017–1.079) | 0.059 |
Non WNT/SHH | 0.267(0.039–1.827) | 0.179 |
NOS | 0.322(0.044–2.363) | 0.265 |
M stage at diagnosis | ||
M0 | Ref | |
M+ | 1.726(0.624–4.779) | 0.293 |
Chemotherapy before RT | ||
No | Ref | |
Yes | 0.535(0.193–1.478) | 0.227 |
Residual disease site before RT | ||
Brain | Ref | |
Spinal cord | 0.690(0.209–2.274) | 0.542 |
Borth | 6.481(2.261–18.581) | 0.001 |
Concurrent chemotherapy | ||
No | Ref | |
Yes | 2.228(0.465–10.666) | 0.316 |
Radiotherapy mode | ||
IMRT | Ref | |
TOMO | 0.885(0.268–2.926) | 0.841 |
CSI dose | ||
< 36 Gy | Ref | |
≥ 36 Gy | 7.089(0.876–57.392) | 0.066 |
Radiotherapy dose | ||
≤ 54 Gy | Ref | |
> 54 Gy | 2.656(0.345–20.444) | 0.348 |
Forward-stepwise model | ||
Residual disease site before RT | ||
Brain | Ref | |
Spinal cord | 0.900(0.363–2.229) | 0.820 |
Borth | 7.312(3.375–15.845) | < 0.001 |