Table 2 Factors associated with DFS in patients with node-positive early-stage cervical cancer

Age (years)

0.963

 ≤44

83

1

 > 44

77

0.983 (0.485–1.993)

Body mass index (Kg/m²)

0.054

0.119

 ≤23.0

80

1

 > 23.0

80

0.700 (0.484–1.013)

Operation approach

0.433

 Open

122

1

 Laparoscopy

38

1.351 (0.634–2.879)

Neoadjuvant chemotherapy

0.127

 No

105

1

 Yes

55

1.732 (0.849–3.534)

Ovarian preservation

0.438

 No

95

1

 Yes

65

0.748 (0.358–1.563)

Histology

0.014

0.029

 Squamous

128

1

1

 Non-squamous

32

1.577 (1.081 -2.300)

1.526 (1.044–2.232)

Tumor differentiation

0.075

0.052

 Well to moderate

71

1

 Poorly

89

1.960 (0.922–4.167)

Tumor size (cm)

0.461

 ≤2

20

1

 2–4

84

0.610 (0.217–1.713)

 >4

56

0.936 (0.333–2.630)

Depth of invasion

0.211

 Inner layer

19

1

 Middle layer

60

4.466 (0.589–33.856)

 Outer layer

81

5.204 (0.687–39.426)

Vaginal invasion

0.654

 Negative

114

1

 Positive

46

1.188 (0.559–2.523)

LVSI

0.834

 Negative

43

1

 Positive

117

1.084 (0.509–2.310)

No. of LN resection

0.390

 ≤33

84

1

 ≥ 34

76

1.361 (0.672–2.756)

No. of positive LN

0.018

0.036

 ≤3

134

1

1

 ≥ 4

26

2.484 (1.140–5.416)

1.521 (1.027–2.252)

Common iliac or para-aortic LNM

0.144

 Negative

143

1

 Positive

17

1.923 (0.788–4.694)

Bilateral pelvic LNM

0.112

 Unilateral

106

1

 Bilateral

54

1.763 (0.869–3.579)

Time interval to CRT

0.911

 ≤6 weeks

90

1

 > 6 weeks

70

0.960 (0.465–1.983)

Brachytherapy

0.724

 No

102

1

 Yes

58

0.873 (0.411–1.856)

Consolidated chemotherapy

0.737

 No

106

1

 Yes

54

1.134 (0.543–2.369)