Table 3 Factors associated with OS in patients with node-positive early-stage cervical cancer

Age (years)

0.841

 ≤44

83

1

 > 44

77

1.124 (0.359–3.521)

BMI (Kg/m²)

0.455

 ≤23.0

80

1

 > 23.0

80

0.646 (0.204–2.050)

Operation approach

0.953

 Open

122

1

 Laparoscopy

38

0.961 (0.258–3.583)

Neoadjuvant chemotherapy

0.828

 No

105

1

 Yes

55

0.876 (0.265–2.895)

Ovarian preservation

0.210

 No

95

1

 Yes

65

0.442 (0.119–1.639)

Histology

< 0.001

0.004

 Squamous

128

1

1

 Non-squamous

32

2.467 (1.389–4.380)

5.625 (1.750 -18.081)

Tumor differentiation

0.041

0.041

 Well to moderate

71

1

1

 Poorly

89

4.327 (0.939–19.925)

5.017 (1.070 -23.522)

Tumor size (cm)

0.879

 ≤2

20

1

 2–4

84

1.154 (0.138–9.664)

 >4

56

1.508 (0.173–13.115)

Depth of invasion

0.102

 Inner layer

19

1

 Middle layer

60

16170.510

 Outer layer

81

44740.536

Vaginal invasion

0.375

 Negative

114

1

 Positive

46

1.672 (0.530–5.279)

LVSI

0.246

 Negative

43

1

 Positive

117

2.394 (0.523–10.955)

No. of LN resection

0.086

0.382

 ≤33

84

1

 ≥34

76

2.751 (0.826–9.167)

No. of positive LN

0.008

 ≤3

134

1

< 0.001

1

 ≥4

26

2.600 (1.435–4.710)

5.158 (1.53017.383)

Common iliac or para-aortic LNM

0.463

 Negative

143

1

 Positive

17

1.762 (0.380–8.161)

Bilateral pelvic LNM

0.040

0.752

 Unilateral

106

1

 Bilateral

54

3.159 (0.991–10.065)

Time interval to CRT

0.789

 ≤6 weeks

90

1

 > 6 weeks

70

0.847 (0.252–2.844)

Brachytherapy

0.960

 No

1

 Yes

58

0.970 (0.292–3.225)

Consolidated CT

0.249

 No

106

1

 Yes

54

1.924 (0.619–5.976)