Fig. 4

In vivo evaluation of the irradiation of solid tumors using I125 seeds. a. Mean tumor volume of MDA-MB-231 tumors; each tumor volume was normalized to the same tumor volume on treatment day (day 12): nontreated tumors (control, blue, n = 7) and irradiated tumors (irradiated, black, n = 9). Cells were injected into NodRag1 mice on day 0. b. Fold change between the mean tumor volume on the day of irradiation and the mean tumor volume on the last day of the experiment. c. Mean tumor volume of MCA-205 tumors. Each tumor volume was normalized to the same tumor volume on treatment day (day 10): nontreated tumors (control, blue, n = 6) and irradiated tumors (irradiated, black, n = 9). C57Bl/6 mice were injected on day 0. d. Fold change between the mean tumor volume on the day of irradiation and the mean tumor volume on the last day of the experiment. For a and c, error bars represent the standard error of the mean (mixed-effects model with Geisser–Greenhouse correction). In c, please note that the error bars for the irradiated group are included and are smaller than the squared symbol