Table 2 Mouse skin reaction grading tool (from Iwakawa et al.)

0.5

50/50 doubtful if there is any difference from normal

1-

Definite but slight abnormality

1

Definite abnormality with reddening

1+

Severe reddening and/or white scales and/or puffiness

1.5

Moist breakdown in one very small area, with scaly or crusty appearance

1.5+

Moist desquamation in small areas (more definite than 1.5)

2

Breakdown of large area, possibly moist in places

2.5

Breakdown of large areas of skin with definite moist exudate

3

Breakdown of moist skin with moist exudate

3.5

Complete moist breakdown of limb - often stuck to body