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Table 3 Univariate and multivariate analysis correlation with vertebral compression fracture

From: Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk

 

Univariate analysis

Multivariable analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

Age

1.02 (0.98–1.05)

0.211

  

Sex

1.75 (0.85–3.61)

0.132

  

Osteoporosis

0.85 (0.20–3.59)

0.833

  

Steroid use  4 weeks

2.98 (1.21–7.36)

0.023

3.60 (1.36–9.51)

0.011

Antiresorptive medicine

1.12 (0.52–2.40)

0.772

  

Bilsky spinal compression grade

3.22 (1.55–6.69)

0.002

1.90 (0.88–4.10)

0.091

SINS score

1.63 (1.37–1.94)

< 0.001

3.63 (1.39–9.46)

0.001

EPD

6.02 (2.46–14.76)

< 0.001

4.16 (1.57–11.05)

0.004

Adverse pathology

3.26 (1.58–6.71)

0.001

2.98 (1.42–6.30)

0.004

Prescribed dose (BED10)

0.95 (0.91–1.01)

0.073

  

PTV- volume

1.01 (0.99–1.01)

0.94

  

Circumferential radiotherapy

2.35 (1.11–4.97)

0.022

1.81 (0.081-4.03)

0.150

  1. abbreviations: BED10: biologically effective dose alpha/beta 10; PTV: planning target volume; EPD: endplate disruption; SINS: spine instability neoplastic score