Table 5 Univariate analysis and multivariate Cox regression for prognostic factors

Age (≥ 60 vs. <60)

1.385

1.037–1.848

0.027

Gender (Male vs. Female)

0.998

0.752–1.325

0.991

Smoking history (Yes vs. No)

1.343

1.020–1.769

0.036

1.335

1.010–1.765

0.042

Comorbidity (Yes vs. No)

1.156

0.890–1.532

0.314

Ki67 (≤ 80%> vs. 80%)

0.905

0.788–1.039

0.156

Syn (Positive vs. Negative)

1.340

0.936–1.919

0.110

CgA (Positive vs. Negative)

1.207

0.576–1.352

0.566

CD56 (Positive vs. Negative )

0.883

0.576–1.352

0.566

Surgery (Yes vs. No)

0.544

0.412–0.718

< 0.001

0.490

0.365–0.660

< 0.001

Radiotherapy (Yes vs. No)

0.941

0.720–1.231

0.657

0.711

0.533–0.949

0.020

Immunotherapy (Yes vs. No)

0.820

0.506–1.330

0.422

Anti-angiogenic (Yes vs. No)

0.958

0.625–1.469

0.843

Tumor location ( Middle thoracic vs. Others)

0.915

0.701–1.195

0.514

TNM stage (I-II vs. III-IV)

0.671

0.513–0.877

0.003